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colony stimulating factor 1 receptor (CSF1R-autoinhibited)

Target Class
Kinase
Family
TK
Official Symbol
CSF1R
Entrez Gene ID
1436
Species
Human
Accession Number
NP_005202.2
Alias Names
C-FMS; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSF-1R; CSFR; FIM2; FMS; FMS proto-oncogene; HDLS; M-CSF-R; McDonough feline sarcoma viral (v-fms) oncogene homolog; colony stimulating factor 1 receptor; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; proto-oncogene c-Fms
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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