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checkpoint kinase 2 (CHEK2)

Target Class
Kinase
Family
CAMK
Official Symbol
CHEK2
Entrez Gene ID
11200
Species
Human
Accession Number
NP_001005735.1
Alias Names
CDS1; CHK2; CHK2 (checkpoint, S.pombe) homolog; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); HuCds1; LFS2; PP1425; RAD53; cds1 homolog; checkpoint kinase 2; checkpoint-like protein CHK2; hCds1; protein kinase CHK2; serine/threonine-protein kinase Chk2
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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