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cyclin-dependent kinase 7 (CDK7)

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
39 KDa protein kinase; CAK; CAK1; CDK-activating kinase 1; CDKN7; HCAK; MO15; STK1; TFIIH basal transcription factor complex kinase subunit; cell division protein kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; p39 Mo15; p39MO15; protein kinase; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; serine/threonine-protein kinase 1
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC

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