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cyclin-dependent kinase 4 (CDK4-cyclinD3)

Target Class
Kinase
Family
CMGC
Official Symbol
CDK4
Entrez Gene ID
1019
Species
Human
Accession Number
NP_000066.1
Alias Names
CMM3; PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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