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cyclin-dependent kinase 2 (CDK2)

Target Class
Kinase
Family
CMGC
Official Symbol
CDK2
Entrez Gene ID
1017
Species
Human
Accession Number
NP_001789.2
Alias Names
cdc2-related protein kinase; cell devision kinase 2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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