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calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2)

Target Class
Kinase
Family
Other
Official Symbol
CAMKK2
Entrez Gene ID
10645
Species
Human
Accession Number
NP_006540.3
Alias Names
CAMKK; CAMKK beta protein; CAMKKB; caM-KK 2; caM-KK beta; caM-kinase kinase 2; caM-kinase kinase beta; calcium/calmodulin-dependent protein kinase beta; calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta
Background
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases. [provided by RefSeq, Jul 2008]
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