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calcium/calmodulin-dependent protein kinase II alpha (CAMK2A)

Target Class
Kinase
Family
CAMK
Official Symbol
CAMK2A
Entrez Gene ID
815
Species
Human
Accession Number
NP_741960.1
Alias Names
CAMKA; CaM kinase II alpha subunit; CaM-kinase II alpha chain; CaMK-II alpha subunit; CaMKIINalpha; caM kinase II subunit alpha; caMK-II subunit alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha
Background
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
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Related Group Members: CAMK
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