Biological Information | |
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Background Information: | Binding of stem cell factor (SCF) to C-Kit receptor tyrosine kinase induces homodimeriziaton and intermolecular tyrosine phosphorylation of the receptor, creating docking sites for a number of SH2-containing signal transduction molecules. These include phosphatidylinositol 3'-kinase (PI 3K) and phospholipase C-1, Stat1, the Src family kinases Src, Lyn, and Fyn, and the GTPase activating protein GAP. Mutation in Kit which result in ligand-independent activation of the kinase were found to be associated with human gastrointestinal stromal tumors and mastocytosis.
GenBank X06182 |
Target Class: | Kinase |
Family: | Receptor Tyrosine Kinase |
Accession Number: | NM_000222.2; NM_001093772.1 |
Target Name: | c-Kit |
Target Aliases: | KIT, C-Kit, PBT, CD117, SCFR, c-kit |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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