Targets / Kinase / c-KIT
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v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
c-KIT
Species
Human
Accession Number
NM_000222.2
Alias Names
C-Kit; CD117; PBT; SCFR; mast/stem cell growth factor receptor Kit; p145 c-kit; piebald trait; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Background
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0853C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0853E3CP16M
Receptor Phosphorylation U2OS Human 93-0853E3CP16L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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