Targets / Kinase / BUB1

BUB1 mitotic checkpoint serine/threonine kinase (BUB1)

Target Class
Kinase
Family
Other
Official Symbol
BUB1
Entrez Gene ID
699
Species
Human
Accession Number
NP_004327.1
Alias Names
BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1A; BUB1L; budding uninhibited by benzimidazoles 1 (yeast homolog); budding uninhibited by benzimidazoles 1 homolog (yeast); hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
Background
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq, Jul 2008]
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