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BMX non-receptor tyrosine kinase (BMX)

Target Class
Kinase
Family
TK
Official Symbol
BMX
Entrez Gene ID
660
Species
Human
Accession Number
NP_001712.1
Alias Names
BMX non-receptor tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; NTK38 tyrosine kinase; PSCTK2; PSCTK3; bone marrow tyrosine kinase gene in chromosome X protein; cytoplasmic tyrosine-protein kinase BMX; epithelial and endothelial tyrosine kinase
Background
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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