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bone morphogenetic protein receptor, type IB (BMPR1B)

Target Class
Kinase
Family
TKL
Official Symbol
BMPR1B
Entrez Gene ID
658
Species
Human
Accession Number
NP_001194.1
Alias Names
ALK-6; ALK6; BMP type-1B receptor; BMPR-1B; CDw293; activin receptor-like kinase 6; bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; serine/threonine receptor kinase
Background
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
BMPR1B/ACVR2 Dimerization U2OS Human 93-1010C3
BMPR1B/BMPR2 Dimerization U2OS Human 93-1053C3
BMPR1B/ACVR2B Dimerization U2OS Human 93-1052C3
Assay Measures Background Species Assay Kit
BMPR1B/ACVR2 Dimerization U2OS Human 93-1010E3CP0S
BMPR1B/ACVR2 Dimerization U2OS Human 93-1010E3CP0M
BMPR1B/ACVR2 Dimerization U2OS Human 93-1010E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available