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mitogen-activated protein kinase kinase kinase 6 (ASK2)

Target Class
Kinase
Family
STE
Official Symbol
MAP3K6
Entrez Gene ID
9064
Species
Human
Accession Number
NP_004663.3
Alias Names
ASK2; MAPKKK6; MEKK6; apoptosis signal regulating kinase 2; apoptosis signal-regulating kinase 2; mitogen-activated protein kinase kinase kinase 6
Background
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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