Targets / Kinase / AMPK-alpha2

protein kinase, AMP-activated, alpha 2 catalytic subunit (AMPK-alpha2)

Target Class
Kinase
Family
CAMK
Official Symbol
PRKAA2
Entrez Gene ID
5563
Species
Human
Accession Number
NP_006243.2
Alias Names
5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK; AMPK subunit alpha-2; AMPK-alpha-2 chain; AMPK2; AMPKa2; PRKAA; protein kinase, AMP-activated, alpha 2 catalytic subunit
Background
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
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Related Group Members: CAMK
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