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v-akt murine thymoma viral oncogene homolog 2 (AKT2)

Target Class
Kinase
Family
AGC
Official Symbol
AKT2
Entrez Gene ID
208
Species
Human
Accession Number
NP_001617.1
Alias Names
HIHGHH; PKB beta; PKBB; PKBBETA; PRKBB; RAC-BETA; RAC-PK-beta; RAC-beta serine/threonine-protein kinase; murine thymoma viral (v-akt) homolog-2; protein kinase Akt-2; protein kinase B beta; rac protein kinase beta; v-akt murine thymoma viral oncogene homolog 2
Background
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
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Related Group Members: AGC
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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