Targets / Kinase / ADCK3
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coenzyme Q8A (ADCK3)

Target Class
Kinase
Family
Atypical
Official Symbol
CABC1
Entrez Gene ID
56997
Species
Human
Accession Number
NP_064632.2
Alias Names
ARCA2; CABC1; COQ8; SCAR9; aarF domain containing kinase 3; aarF domain-containing protein kinase 3; chaperone activity of bc1 complex-like, mitochondrial; chaperone, ABC1 activity of bc1 complex homolog; chaperone, ABC1 activity of bc1 complex homolog (S. pombe); chaperone, ABC1 activity of bc1 complex like (S. pombe); chaperone-ABC1 (activity of bc1 complex, S.pombe)-like; coenzyme Q8 homolog
Background
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
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