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activin A receptor, type I (ACVR1)

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TGF-B superfamily receptor type I; TSRI; activin A receptor, type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL

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Assay Measures Background Species Cell Line
ACVR1/ACVR2 Dimerization U2OS Human 93-0906C3
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan