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activin A receptor, type I (ACVR1)

Target Class
Kinase
Family
TKL
Official Symbol
ACVR1
Entrez Gene ID
90
Species
Human
Accession Number
NP_001096.1
Alias Names
ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TGF-B superfamily receptor type I; TSRI; activin A receptor, type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1
Background
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: TKL
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
ACVR1/ACVR2 Dimerization U2OS Human 93-0906C3
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available