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v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) (ABL2)

Target Class
Kinase
Family
TK
Official Symbol
ABL2
Entrez Gene ID
27
Species
Human
Accession Number
NP_005149.4
Alias Names
ABLL; ARG; Abelson tyrosine-protein kinase 2; abelson-related gene protein; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Background
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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