Somatostatin receptor 5 (SST5)
- Target Class
- GPCR
- Family
- Somatostatin
- Official Symbol
- SSTR5
- Species
- Human
- Accession Number
- NM_001053
- Alias Names
- SS-5-R; somatostatin receptor 5; somatostatin receptor subtype 5; somatostatin receptor type 5
- Background
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
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Solution Portfolio
Related Family Members:
Somatostatin
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| cAMP |
CHO-K1 |
Human |
95-0133C2 |
| β-Arrestin |
CHO-K1 |
Human |
93-0402C2 |
| β-Arrestin |
U2OS |
Human |
93-0402C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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