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Parathyroid hormone receptor 1 (PTH1)

Target Class
GPCR
Family
Parathyroid hormone
Official Symbol
PTHR1
Species
Human
Accession Number
AY449732
Alias Names
PTH1R; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTHR; PTHR1; parathyroid hormone 1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; seven transmembrane helix receptor
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
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Solution Portfolio

Related Family Members:

Parathyroid hormone
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0315C2
Internalization U2OS Human 93-0770C3
cAMP CHO-K1 Human 95-0118C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0118E2CP2S
cAMP CHO-K1 Human 95-0118E2CP2M
cAMP CHO-K1 Human 95-0118E2CP2L
β-Arrestin CHO-K1 Human 93-0315E2CP0S
β-Arrestin CHO-K1 Human 93-0315E2CP0M
β-Arrestin CHO-K1 Human 93-0315E2CP0L
Internalization U2OS Human 93-0770E3CP0S
Internalization U2OS Human 93-0770E3CP0M
Internalization U2OS Human 93-0770E3CP0L
Assay Readout Background Species Assay Kit
CHO-K1 Human 95-0118Y2-00058
CHO-K1 Human 95-0118Y2-00057
CHO-K1 Human 93-0315Y2-00047
CHO-K1 Human 93-0315Y2-00048
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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