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Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12)

Target Class
GPCR
Family
P2Y
Official Symbol
P2RY12
Species
Human
Accession Number
AY136754
Alias Names
ADP-glucose receptor; ADPG-R; BDPLT8; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; HORK3; P2T(AC); P2Y purinoceptor 12; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; P2Y12 platelet ADP receptor; SP1999; purinergic receptor P2RY12; purinergic receptor P2Y, G-protein coupled, 12; putative G-protein coupled receptor
Background
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

P2Y
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Arrestin Assays
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DiscoveRx PathHunter ß-Arrestin GPCR assays are a cell-based functional assay that quantitatively measures GPCR activation through ß-Arrestin recruitment to activated GPCRs. This offers a simple, yet powerful screening and profiling platform that can be used for almost all Gi-, Gs-, or Gq-coupled receptor. Learn more about our Arrestin Assays.

Assay Readout Background Cell Lines
?

DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
?

DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
?

DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

β-Arrestin-2 CHO-K1 93-0262C2 eXpress
mouse
Yes
Receptor Internalization
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DiscoveRx PathHunter GPCR Internalization Assays are a non-imaging, antibody-free method to measure GPCR endocytosis in intact cells. This simple, chemiluminescent based assay is able to detect total GPCR internalization and activated GPCR internalization. Learn more about our Receptor Internalization.

Assay Readout Background Cell Lines
?

DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
?

DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
?

DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

Internalization U2OS 93-0952C3 Yes
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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