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Prostanoid DP2 receptor (mDP2)

Target Class
GPCR
Family
Prostanoid
Official Symbol
mCRTH2
Species
Mouse
Accession Number
NM_009962.2
Alias Names
DP2; CD294; Crth2; G protein-coupled receptor 44; G-protein coupled receptor 44; Grp45; PGD2 receptor; Ptgdr2; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2; putative G-protein coupled receptor 44
Background
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
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Solution Portfolio

Related Family Members:

Prostanoid
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Mouse 93-0584C2
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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