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Chemokine-Like Receptor 1 (mCMKLR1)

Target Class
GPCR
Family
Chemokine
Official Symbol
mCMKLR1
Species
Mouse
Accession Number
NM_008153.2
Alias Names
ChemR23; DEZ; G-protein coupled receptor 27; G-protein coupled receptor DEZ; Gpcr27; chemerin receptor; chemokine receptor-like 1; chemokine-like receptor 1; mcmklr1
Background
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity).
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Solution Portfolio

Related Family Members:

Chemokine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Mouse 93-0537C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Mouse 93-0537E2MCP0L
β-Arrestin CHO-K1 Mouse 93-0537E2MCP0M
β-Arrestin CHO-K1 Mouse 93-0537E2MCP0S
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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