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5-hydroxytryptamine receptor 2A (5HT2A)

Target Class
GPCR
Family
5-Hydroxytryptamine
Official Symbol
HTR2A
Species
Human
Accession Number
NM_000621.3
Alias Names
5-HT-2A; 5-HT2 receptor; 5-HT2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; HTR2; serotonin 5-HT-2A receptor
Background
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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Solution Portfolio

Related Family Members:

5-Hydroxytryptamine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin U2OS Human 93-0401C3
Internalization U2OS Human 93-0807C3
Assay Readout Background Species Assay Kit
β-Arrestin U2OS Human 93-0401E3CP19S
β-Arrestin U2OS Human 93-0401E3CP19M
β-Arrestin U2OS Human 93-0401E3CP19L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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