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Gastrin releasing peptide receptor (BB2)

Target Class
GPCR
Family
Bombesin
Official Symbol
GRPR
Species
Human
Accession Number
NM_005314
Alias Names
GRP-R; GRP-preferring bombesin receptor; gastrin-releasing peptide receptor
Background
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Bombesin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin HEK 293 Human 93-0229C1
β-Arrestin U2OS Human 93-0229C3
Internalization U2OS Human 93-0667C3
Assay Readout Background Species Assay Kit
β-Arrestin U2OS Human 93-0229E3CP5S
β-Arrestin U2OS Human 93-0229E3CP5M
β-Arrestin U2OS Human 93-0229E3CP5L
Internalization U2OS Human 93-0667E3CP5S
Internalization U2OS Human 93-0667E3CP5M
Internalization U2OS Human 93-0667E3CP5L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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