Gastrin releasing peptide receptor (BB2)
- Target Class
- GPCR
- Family
- Bombesin
- Official Symbol
- GRPR
- Species
- Human
- Accession Number
- NM_005314
- Alias Names
- GRP-R; GRP-preferring bombesin receptor; gastrin-releasing peptide receptor
- Background
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Bombesin
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
HEK 293 |
Human |
93-0229C1 |
| β-Arrestin |
U2OS |
Human |
93-0229C3 |
| Internalization |
U2OS |
Human |
93-0667C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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