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Metabotropic glutamate receptor 6 (mGlu6)

Target Class
GPCR
Family
Metabotropic glutamate
Official Symbol
GRM6
Species
Human
Accession Number
NM_000843
Alias Names
CSNB1B; GPRC1F; MGLUR6; glutamate receptor, metabotropic 6; mGlu6; metabotropic glutamate receptor 6
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
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Solution Portfolio

Related Family Members:

Metabotropic glutamate
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
cAMP CHO-K1 Human 95-0105C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0105E2CP24S
cAMP CHO-K1 Human 95-0105E2CP24M
cAMP CHO-K1 Human 95-0105E2CP24L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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