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G-protein coupled receptor 84 (GPR84)

Target Class
Class A Orphan
Official Symbol
Accession Number
Alias Names
EX33; G protein-coupled receptor 84; G-protein coupled receptor 84; GPCR4; inflammation-related G protein-coupled receptor EX33; inflammation-related G-protein coupled receptor EX33
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
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Solution Portfolio

Related Family Members:

Class A Orphan

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0647C2
cAMP CHO-K1 Human 95-0158C2
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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Access your Target with Three Signaling Platforms