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Hydroxycarboxylic acid receptor 1 (HCA1)

Target Class
GPCR
Family
Hydroxycarboxylic acid
Official Symbol
GPR81
Species
Human
Accession Number
NM_032554
Alias Names
HCAR1; G protein-coupled receptor 104; G protein-coupled receptor 81; G-protein coupled receptor 104; G-protein coupled receptor 81; GPR104; GPR81; HCA1; LACR1; T-cell activation G protein-coupled receptor; TA-GPCR; hydroxy-carboxylic acid receptor 1; hydroxycarboxylic acid receptor 1; lactate receptor 1
Background
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
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Solution Portfolio

Related Family Members:

Hydroxycarboxylic acid
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Second Messenger
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GPCR activation is often accompanied by the release of second messenger signaling molecules such as cAMP, Calcium, IP3 and cGMP, based on its G-protein binding partners. DiscoveRx offers a variety of cell lines and kits to study these second messenger signaling molecules as a measure of GPCR activity. Learn more about our Second Messengers.

Assay Readout Background Cell Lines
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DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
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DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
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DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

cAMP CHO-K1 95-0149C2 Yes
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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