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G-protein coupled receptor 31 (GPR31)

Target Class
GPCR
Family
Class A Orphan
Official Symbol
GPR31
Species
Human
Accession Number
NM_005299
Alias Names
12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-HETER; G protein-coupled receptor 31; G-protein coupled receptor 31; HETER; HETER1; bA517H2.2 (G protein-coupled receptor 31); hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31
Background
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.
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Solution Portfolio

Related Family Members:

Class A Orphan
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinHEK 293Human93-0406E1CP1S
β-ArrestinHEK 293Human93-0406E1CP1M
β-ArrestinHEK 293Human93-0406E1CP1L
β-ArrestinCHO-K1Human93-0406E2CP2S
β-ArrestinCHO-K1Human93-0406E2CP2M
β-ArrestinCHO-K1Human93-0406E2CP2L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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