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G-protein coupled receptor 31 (GPR31)

Target Class
GPCR
Family
Class A Orphan
Official Symbol
GPR31
Species
Human
Accession Number
NM_005299
Alias Names
12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-HETER; G protein-coupled receptor 31; G-protein coupled receptor 31; HETER; HETER1; bA517H2.2 (G protein-coupled receptor 31); hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31
Background
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.
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Solution Portfolio

Related Family Members:

Class A Orphan
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0406C2
Assay Readout Background Species Assay Kit
β-Arrestin HEK 293 Human 93-0406E1CP1S
β-Arrestin HEK 293 Human 93-0406E1CP1M
β-Arrestin HEK 293 Human 93-0406E1CP1L
β-Arrestin CHO-K1 Human 93-0406E2CP2S
β-Arrestin CHO-K1 Human 93-0406E2CP2M
β-Arrestin CHO-K1 Human 93-0406E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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