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Hydroxycarboxylic acid receptor 3 (HCA3)

Target Class
GPCR
Family
Hydroxycarboxylic acid
Official Symbol
GPR109B
Species
Human
Accession Number
NM_006018
Alias Names
HCAR3; NIC2; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; GTP-binding protein; HCA3; HM74; PUMAG; Puma-g; hydroxy-carboxylic acid receptor 3; hydroxycarboxylic acid receptor 3; niacin receptor 2; nicotinic acid receptor 2; putative chemokine receptor
Background
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
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Solution Portfolio

Related Family Members:

Hydroxycarboxylic acid
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
cAMPCHO-K1Human95-0141C2
β-ArrestinCHO-K1Human93-0791C2
 
Assay Readout ▲BackgroundSpeciesAssay Kit
cAMPCHO-K1Human95-0141E2CP2S
cAMPCHO-K1Human95-0141E2CP2M
cAMPCHO-K1Human95-0141E2CP2L
β-ArrestinCHO-K1Human93-0791E2CP2S
β-ArrestinCHO-K1Human93-0791E2CP2M
β-ArrestinCHO-K1Human93-0791E2CP2L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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