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Hydroxycarboxylic acid receptor 3 (HCA3)

Target Class
GPCR
Family
Hydroxycarboxylic acid
Official Symbol
GPR109B
Species
Human
Accession Number
NM_006018
Alias Names
HCAR3; NIC2; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; GTP-binding protein; HCA3; HM74; PUMAG; Puma-g; hydroxy-carboxylic acid receptor 3; hydroxycarboxylic acid receptor 3; niacin receptor 2; nicotinic acid receptor 2; putative chemokine receptor
Background
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
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Solution Portfolio

Related Family Members:

Hydroxycarboxylic acid
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0791C2
cAMP CHO-K1 Human 95-0141C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0141E2CP2S
cAMP CHO-K1 Human 95-0141E2CP2M
cAMP CHO-K1 Human 95-0141E2CP2L
β-Arrestin CHO-K1 Human 93-0791E2CP2S
β-Arrestin CHO-K1 Human 93-0791E2CP2M
β-Arrestin CHO-K1 Human 93-0791E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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