G protein-coupled bile acid receptor 1 (GPBA)
- Target Class
- GPCR
- Family
- Bile acid
- Official Symbol
- GPBAR1
- Species
- Human
- Accession Number
- NM_001077194.1
- Alias Names
- BG37; G protein-coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; GPCR19; GPR131; M-BAR; TGR5; hBG37; hGPCR19; membrane bile acid receptor; membrane-type receptor for bile acids
- Background
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Bile acid
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
U2OS |
Human |
93-0794C3 |
| cAMP |
CHO-K1 |
Human |
95-0049C2 |
| Assay Qualified With |
Assay Measures |
Background |
Species |
Assay Kit |
| TGR5 Receptor Agonist |
cAMP |
CHO-K1 |
Human |
95-0049Y2-00140 |
| TGR5 Receptor Agonist |
cAMP |
CHO-K1 |
Human |
95-0049Y2-00139 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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