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G protein-coupled bile acid receptor 1 (GPBA)

Target Class
GPCR
Family
Bile acid
Official Symbol
GPBAR1
Species
Human
Accession Number
NM_001077194.1
Alias Names
BG37; G protein-coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; GPCR19; GPR131; M-BAR; TGR5; hBG37; hGPCR19; membrane bile acid receptor; membrane-type receptor for bile acids
Background
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Bile acid
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
cAMPCHO-K1Human95-0049C2
β-ArrestinU2OSHuman93-0794C3
 
Assay Readout ▲BackgroundSpeciesAssay Kit
cAMPCHO-K1Human95-0049E2CP2S
cAMPCHO-K1Human95-0049E2CP2M
cAMPCHO-K1Human95-0049E2CP2L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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