Gonadotropin-releasing hormone receptor (GnRH)
- Target Class
- Gonadotropin-releasing hormone
- Official Symbol
- Accession Number
- Alias Names
- GNRHR1; GRHR; LHRHR; LRHR; gnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; luliberin receptor; type I GnRH receptor
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]+ Show More
Related Family Members:
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GPCR activation is often accompanied by the release of second messenger signaling molecules such as cAMP, Calcium, IP3 and cGMP, based on its G-protein binding partners. DiscoveRx offers a variety of cell lines and kits to study these second messenger signaling molecules as a measure of GPCR activity. Learn more about our Second Messengers.
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