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Gonadotropin-releasing hormone receptor (GnRH)

Target Class
GPCR
Family
Gonadotropin-releasing hormone
Official Symbol
GNRHR
Species
Human
Accession Number
NM_000406.2
Alias Names
GNRHR1; GRHR; LHRHR; LRHR; gnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; luliberin receptor; type I GnRH receptor
Background
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Gonadotropin-releasing hormone
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