Growth hormone secretagogue receptor 1b (GHSR1b)
- Target Class
- GPCR
- Family
- Class A Orphan
- Official Symbol
- GHSR1b
- Species
- Human
- Accession Number
- NM_004122
- Alias Names
- GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor; growth hormone secretagogue receptor; growth hormone secretagogue receptor type 1
- Background
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]
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Solution Portfolio
Related Family Members:
Class A Orphan
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0354C2A |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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