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Formylpeptide receptor-like 1 (FPR2/ALX)

Target Class
GPCR
Family
Formylpeptide
Official Symbol
FPRL1
Species
Human
Accession Number
AY225226
Alias Names
ALXR; FMLP-R-I; FMLP-R-II; FMLP-related receptor I; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4 receptor; LXA4R; N-formyl peptide receptor 2; RFP; formyl peptide receptor 2; formyl peptide receptor-like 1; lipoxin A4 receptor (formyl peptide receptor related)
Background
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
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Solution Portfolio

Related Family Members:

Formylpeptide
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0319C2
Internalization U2OS Human 93-0666C3
cAMP CHO-K1 Human 95-0044C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0044E2CP2S
cAMP CHO-K1 Human 95-0044E2CP2M
cAMP CHO-K1 Human 95-0044E2CP2L
β-Arrestin CHO-K1 Human 93-0319E2CP2S
β-Arrestin CHO-K1 Human 93-0319E2CP2M
β-Arrestin CHO-K1 Human 93-0319E2CP2L
Internalization U2OS Human 93-0666E3CP0S
Internalization U2OS Human 93-0666E3CP0M
Internalization U2OS Human 93-0666E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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