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Coagulation factor II (thrombin) receptor-like 1 (PAR2) (PAR2)

Target Class
GPCR
Family
Protease activated
Official Symbol
F2RL1
Species
Human
Accession Number
NM_005242.4
Alias Names
G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; protease-activated receptor 2; proteinase-activated receptor 2; proteinase-activated receptor-2; thrombin receptor-like 1
Background
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Protease activated
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
Internalization U2OS Human 93-0747C3
Calcium CHO-K1 Human 95-1006C2
β-Arrestin HEK 293 Human 93-0235C1
β-Arrestin U2OS Human 93-0235C3
Assay Readout Background Species Assay Kit
Internalization U2OS Human 93-0747E3CP5S
Internalization U2OS Human 93-0747E3CP5M
Internalization U2OS Human 93-0747E3CP5L
β-Arrestin HEK 293 Human 93-0235E1CP0S
β-Arrestin HEK 293 Human 93-0235E1CP0M
β-Arrestin HEK 293 Human 93-0235E1CP0L
β-Arrestin U2OS Human 93-0235E3CP0S
β-Arrestin U2OS Human 93-0235E3CP0M
β-Arrestin U2OS Human 93-0235E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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