Dopamine Receptor D4 (D4)
- Target Class
- GPCR
- Family
- Dopamine
- Official Symbol
- DRD4
- Species
- Human
- Accession Number
- NM_000797.2
- Alias Names
- D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; dopamine D4 receptor; dopamine receptor D4; seven transmembrane helix receptor
- Background
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Dopamine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0690C2 |
| cAMP |
CHO-K1 |
Human |
95-0123C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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