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Dopamine Receptor D4 (D4)

Target Class
GPCR
Family
Dopamine
Official Symbol
DRD4
Species
Human
Accession Number
NM_000797.2
Alias Names
D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; dopamine D4 receptor; dopamine receptor D4; seven transmembrane helix receptor
Background
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Dopamine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0690C2
cAMP CHO-K1 Human 95-0123C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0690E2CP0S
β-Arrestin CHO-K1 Human 93-0690E2CP0M
β-Arrestin CHO-K1 Human 93-0690E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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