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Dopamine Receptor D4 (D4)

Target Class
GPCR
Family
Dopamine
Official Symbol
DRD4
Species
Human
Accession Number
NM_000797.2
Alias Names
D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; dopamine D4 receptor; dopamine receptor D4; seven transmembrane helix receptor
Background
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Dopamine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesCell Line
cAMPCHO-K1Human95-0123C2
β-ArrestinCHO-K1Human93-0690C2
 
Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinCHO-K1Human93-0690E2CP0S
β-ArrestinCHO-K1Human93-0690E2CP0M
β-ArrestinCHO-K1Human93-0690E2CP0L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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