Dopamine Receptor D3 (D3)
- Target Class
- GPCR
- Family
- Dopamine
- Official Symbol
- DRD3
- Species
- Human
- Accession Number
- NM_000796.3
- Alias Names
- D(3) dopamine receptor; D3DR; ETM1; FET1; dopamine D3 receptor; dopamine receptor D3; essential tremor 1
- Background
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Dopamine
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0591C2 |
|
U2OS |
Human |
93-0591C3 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
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|
Available |
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