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Chemokine (C-X-C motif) receptor 1 (CXCR1)

Target Class
GPCR
Family
Chemokine
Official Symbol
CXCR1
Species
Human
Accession Number
NM_000634
Alias Names
C-C; C-C-CKR-1; C-X-C chemokine receptor type 1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXC-R1; CXCR-1; IL-8 receptor type 1; IL-8R A; IL8R1; IL8RA; IL8RBA; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A
Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Chemokine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin U2OS Human 93-0226C3
Internalization U2OS Human 93-0659C3
cAMP CHO-K1 Human 95-0073C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0073E2CP2S
cAMP CHO-K1 Human 95-0073E2CP2M
cAMP CHO-K1 Human 95-0073E2CP2L
β-Arrestin U2OS Human 93-0226E3CP0S
β-Arrestin U2OS Human 93-0226E3CP0M
β-Arrestin U2OS Human 93-0226E3CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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