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Chemokine (C-C motif) receptor 8 (CCR8)

Target Class
GPCR
Family
Chemokine
Official Symbol
CCR8
Species
Human
Accession Number
NM_005201.3
Alias Names
C-C chemokine receptor type 8; CC chemokine receptor 8; CC chemokine receptor CHEMR1; CC-CKR-8; CC-chemokine receptor chemr1; CCR-8; CDw198; CKRL1; CMKBR8; CMKBRL2; CY6; GPRCY6; TER1; chemokine (C-C motif) receptor 8; chemokine (C-C) receptor 8; chemokine (C-C) receptor-like 2; chemokine receptor-like 1
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Chemokine
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0196C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0196E2CP0S
β-Arrestin CHO-K1 Human 93-0196E2CP0M
β-Arrestin CHO-K1 Human 93-0196E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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