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Chemokine (C-C motif) receptor 2 (CCR2)

Target Class
GPCR
Family
Chemokine
Official Symbol
CCR2
Species
Human
Accession Number
NM_001123396
Alias Names
C-C chemokine receptor type 2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1 receptor; MCP-1-R; chemokine (C-C motif) receptor 2; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Background
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
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Solution Portfolio

Related Family Members:

Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin HEK 293 Human 93-0192C1
Internalization U2OS Human 93-0679C3
β-Arrestin CHO-K1 Human 93-0192C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0192E2CP0S
β-Arrestin CHO-K1 Human 93-0192E2CP0M
β-Arrestin CHO-K1 Human 93-0192E2CP0L
Internalization U2OS Human 93-0679E3CP5S
Internalization U2OS Human 93-0679E3CP5M
Internalization U2OS Human 93-0679E3CP5L
Assay Readout Background Species Assay Kit
CHO-K1 Human 93-0192Y2-00062
CHO-K1 Human 93-0192Y2-00061
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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