Find a Product

Calcitonin receptor-like (Calcitonin receptor-like receptor)

Target Class
GPCR
Family
Calcitonin
Official Symbol
CALCRL-RAMP1
Species
Human
Accession Number
AY389506
Alias Names
CRLR activity-modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; receptor activity modifying protein 1; receptor activity-modifying protein 1
Background
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]
+ Show More

Solution Portfolio

Related Family Members:

Calcitonin
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0269C2
cAMP CHO-K1 Human 95-0164C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0269E2CP0S
β-Arrestin CHO-K1 Human 93-0269E2CP0M
β-Arrestin CHO-K1 Human 93-0269E2CP0L
cAMP CHO-K1 Human 95-0164E2CP2S
cAMP CHO-K1 Human 95-0164E2CP2M
cAMP CHO-K1 Human 95-0164E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms