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Angiotensin II receptor, type 1 (AT1)

Target Class
GPCR
Family
Angiotensin
Official Symbol
AGTR1
Species
Human
Accession Number
NM_000685
Alias Names
AG2S; AGTR1A; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; angiotensin II receptor, type 1; angiotensin II type-1 receptor; angiotensin receptor 1; angiotensin receptor 1B; type-1 angiotensin II receptor; type-1B angiotensin II receptor
Background
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Angiotensin
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Arrestin Assays
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DiscoveRx PathHunter ß-Arrestin GPCR assays are a cell-based functional assay that quantitatively measures GPCR activation through ß-Arrestin recruitment to activated GPCRs. This offers a simple, yet powerful screening and profiling platform that can be used for almost all Gi-, Gs-, or Gq-coupled receptor. Learn more about our Arrestin Assays.

Assay Readout Background Cell Lines
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DiscoveRx offers stable and validated cell lines of unsurpassed quality and leading performance, engineered using our proprietary EFC technology. These engineered cell lines form the basis of our cell-based assays for a broad range of target classes in a variety of cell backgrounds, ideal for screening and profiling both small molecules and biologics. Learn more about our Cell Lines.

Assay Ready Kits
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DiscoveRx Assay Ready kits are ready-to-ship, ready-to-use kits that contain all the necessary reagents to perform a functional whole-cell assay including frozen pre-validated cells, detection reagents, media and plates, with a simple thaw-plate-read protocol. DiscoveRx offers a variety of Assay Ready kits. Learn more about our Assay Ready Kits.

Orthologs Services
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DiscoveRx offers a variety of service options designed to support you at every stage of drug development. We offer screening and profiling services for small molecules and biologics, using DiscoveRx cell lines anchored in the EFC and competition binding technology platforms. We can develop custom assay solutions tailored to meet your needs and provide scale up options for our cell lines and supporting components. Learn more about DiscoveRx Services.

β-Arrestin-2 CHO-K1 93-0312C2 (β-Arrestin/Ca2+) eXpress
Yes
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
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