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Adrenergic receptor alpha 2C (α2C-adrenoceptor)

Target Class
GPCR
Family
Adrenoceptors
Official Symbol
ADRA2C
Species
Human
Accession Number
NM_000683
Alias Names
ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2CAR; alpha2-AR-C4; a2C
Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Adrenoceptors
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0511C2
cAMP CHO-K1 Human 95-0053C2
Internalization U2OS Human 93-0923C3
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0053E2CP2S
cAMP CHO-K1 Human 95-0053E2CP2M
cAMP CHO-K1 Human 95-0053E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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