Find a Product

Adrenergic receptor alpha 1B (α1B-adrenoceptor)

Target Class
GPCR
Family
Adrenoceptors
Official Symbol
ADRA1B
Species
Human
Accession Number
NM_000679
Alias Names
ADRA1; ALPHA1BAR; adrenergic, alpha-1B-, receptor; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; a1B
Background
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
+ Show More

Solution Portfolio

Related Family Members:

Adrenoceptors
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0274C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0274E2CP0S
β-Arrestin CHO-K1 Human 93-0274E2CP0M
β-Arrestin CHO-K1 Human 93-0274E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
        Available  
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms