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Adrenergic receptor alpha 1B (α1B-adrenoceptor)

Target Class
GPCR
Family
Adrenoceptors
Official Symbol
ADRA1B
Species
Human
Accession Number
NM_000679
Alias Names
ADRA1; ALPHA1BAR; adrenergic, alpha-1B-, receptor; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; a1B
Background
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
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Related Family Members:

Adrenoceptors
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout ▲BackgroundSpeciesAssay Kit
β-ArrestinCHO-K1Human93-0274E2CP0S
β-ArrestinCHO-K1Human93-0274E2CP0M
β-ArrestinCHO-K1Human93-0274E2CP0L
 
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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