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Euchromatic histone-lysine N-methyltransferase 2 (EHMT2)

Target Class
Methyltransferase
Family
Histone methyltransferase
Official Symbol
G9a
Species
Human
Accession Number
NM_006709
Alias Names
BAT8; C6orf30; G9A; G9A histone methyltransferase; GAT8; H3-K9-HMTase 3; HLA-B associated transcript 8; HLA-B-associated transcript 8; KMT1C; NG36; ankyrin repeat-containing protein; chromosome 6 open reading frame 30; euchromatic histone-lysine N-methyltransferase 2; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase EHMT2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; lysine N-methyltransferase 1C; protein G9a
Background
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Technology:

Cell Based
?

DiscoveRx PathHunter and InCELL Hunter Cell-Based Assays are performed in intact living engineered cell lines, enabling you to test protein function in its native environment. These assays are anchored in our proprietary EFC technology and allow drug development for a broad range of target classes. Learn more about our Cell Based Assays.

, Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members: View
Assay Measures Background Species Cell Line
Intracellular Binding A549 Human 96-0003C15
Assay Measures Background Species Assay Kit
Intracellular Binding A549 Human 96-0003E15CP7S
Intracellular Binding A549 Human 96-0003E15CP7M
Intracellular Binding A549 Human 96-0003E15CP7L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan