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mitogen-activated protein kinase kinase kinase 14 (NIK)

Target Class
Checkpoint Receptor
Family
STE
Official Symbol
MAP3K14
Entrez Gene ID
9020
Species
Human
Accession Number
NP_003945.2
Alias Names
FTDCR1B; HS; HSNIK; NF-kappa-beta-inducing kinase; NIK; mitogen-activated protein kinase kinase kinase 14; serine/threonine protein-kinase; serine/threonine-protein kinase NIK
Background
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: STE
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Assay Measures Background Species Cell Line
U2OS Human 93-1059C3
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available         Available