Services / Drug Discovery & Development Services / BioMAP Human Primary Cell Phenotypic Profiling / Systems ELECT
Services

BioMAP® Systems ELECT

    BioMAP Systems ELECT allows the flexibility to choose any individual or combination of available BioMAP Systems to create your own customized BioMAP panel.

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Drug Discovery Applications

  • Statistically compare and rank compounds using potency on key biomarker readouts
  • Discrimination of exemplars using activites that can be correlated with chemical structures to help guide SAR
    • Testing drug combinations
    • Biomarker discovery

Systems ELECT Advantages

  • Complex human primary cells and co-cultures
  • Broad coverage of biology - immune, vascular, and stromal cell microenvironment
  • Flexible approach to BioMAP Systems - create custom panels

This service has a 7-compound minimum
 
Systems ELECT Service

Service
  • Test agent profiling (chemical compounds or biologics) using any, available BioMAP System(s)
  • All biomarker readouts listed for the selected BioMAP System(s), 4 concentrations in triplicate

Description
  • Annotation Identification and analysis of biological relevance of BioMAP biomarker activities
  • Benchmarking Direct comparison of test agent to a specified reference compound from BioMAP Database (as available)

Deliverables
  • Study Report BioMAP profile plots, annotation of biomarker activities with respect to biological significance, graphical overlays of test agent and reference compound profiles (if available), expert data interpretation and collaborative analysis
  • Data Report Log ratio data tables, tables of cytotoxicities and active biomarker readouts

Available Systems & Readouts

System ▲RelevanceCell TypeBiomarker Readout
/3CCardiovascular Disease, Chronic InflammationVenular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, Proliferation, SRB
/4HAllergy, Asthma, OncologyVenular endothelial cellsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD62P/P-Selectin, CD87/uPAR, SRB, VEGFR2
/HDF3CTChronic Inflammation, FibrosisDermal fibroblastsCCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, M-CSF, MMP-1, PAI-I, SRB, TIMP-2
/HDFTChronic Inflammation, FibrosisDermal fibroblastsCollagen I, Collagen III, PAI-I, SRB, TIMP-1, TIMP-2
/HPNoImmune Biology, Vascular BiologyPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, M-CSF, sPGE2, SRB, sTNF-α
/LPSCardiovascular Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, sPGE2, SRB, sTNF-α
/MphgCardiovascular Disease, Chronic Inflammation, RestenosisMacrophages + Venular endothelial cellsCCL2/MCP-1, CCL3/MIP-1 α, CD106/VCAM-1, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, sIL-10, SRB, SRB-Mphg
/MphgNoImmune Biology, Vascular BiologyMacrophages + Venular endothelial cellsCCL2/MCP-1, CCL3/MIP-1 α, CD106/VCAM-1, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, SRB, SRB-Mphg
/SAgAutoimmune Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, Proliferation, SRB
/TH2Allergy, Asthma, OncologyTH2 blasts + Venular endothelial cellsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD38, CD40, CD62E/E-Selectin, CD62P/P-Selectin, CD69, CD87/uPAR, Collagen IV, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, sIL-17A, sIL-17F, SRB
/TH2NoTH2 BiologyTH2 blasts + Venular endothelial cellsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD38, CD40, CD62E/E-Selectin, CD62P/P-Selectin, CD69, CD87/uPAR, Collagen IV, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, sIL-17A, sIL-17F, SRB
3CCardiovascular Disease, Chronic InflammationVenular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, Proliferation, SRB
4HAllergy, Asthma, AutoimmunityVenular endothelial cellsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD62P/P-Selectin, CD87/uPAR, SRB, VEGFR2
BE3CCOPD, Lung InflammationBronchial epithelial cellsCD54/ICAM-1, CD87/uPAR, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, HLA-DR, IL-1 α, Keratin 8/18, MMP-1, MMP-9, PAI-I, SRB, tPA, uPA
BENoEpithelial Biology, Lung BiologyBronchial epithelial cellsCCL26/Eotaxin-3, CD54/ICAM-1, CD87/uPAR, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, HLA-DR, IL-1 α, Keratin 8/18, MMP-1, MMP-9, PAI-I, SRB, tPA, uPA
BF4TAllergy, Asthma, Fibrosis, Lung InflammationBronchial epithelial cells + Dermal fibroblastsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD54/ICAM-1, CD90, CXCL8/IL-8, IL-1 α, Keratin 8/18, MMP-1, MMP-3, MMP-9, PAI-I, SRB, tPA, uPA
BFNoEpithelial Biology, Lung BiologyBronchial epithelial cells + Dermal fibroblastsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD54/ICAM-1, CD90, CXCL8/IL-8, IL-1 α, Keratin 8/18, MMP-1, MMP-3, MMP-9, PAI-I, SRB, tPA, uPA
BTAllergy, Asthma, Autoimmunity, OncologyB cells + Peripheral blood mononuclear cellsB cell Proliferation, PBMC Cytotoxicity, Secreted IgG, sIL-17A, sIL-17F, sIL-2, sIL-6, sTNF-α
BTNoAllergy, Asthma, Autoimmunity, OncologyB cells + Peripheral blood mononuclear cellsB cell Proliferation, PBMC Cytotoxicity, Secreted IgG, sIL-17A, sIL-17F, sIL-2, sIL-6, sTNF-α
CAEC3CCardiovascular Disease, Chronic InflammationCoronary artery endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, PAI-I, Proliferation, SRB
CASM3CCardiovascular Inflammation, RestenosisCoronary artery smooth muscle cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, IL-6, LDLR, M-CSF, PAI-I, Proliferation, Serum Amyloid A, SRB
CASMNoVascular BiologyCoronary artery smooth muscle cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, IL-6, LDLR, M-CSF, PAI-I, Proliferation, Serum Amyloid A, SRB
HDF3CChronic Inflammation, FibrosisDermal fibroblastsCCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, M-CSF, MMP-1, PAI-I, Proliferation_72hr, SRB, TIMP-1, TIMP-2
HDF3CGFChronic Inflammation, FibrosisDermal fibroblastsCCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, M-CSF, MMP-1, PAI-I, Proliferation_72hr, SRB, TIMP-1, TIMP-2
HDFLPSAutoimmune Disease, Chronic Inflammation, Infection responsesDermal fibroblasts + Peripheral blood mononuclear cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, M-CSF, MMP-1, sIL-10, sIL-17A, sIL-17F, sIL-2, sIL-6, SRB, sTGF-β 1, sTNF-α, sVEGF
HDFNoFibroblast BiologyDermal fibroblastsCCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, M-CSF, MMP-1, PAI-I, Proliferation_72hr, SRB, TIMP-1, TIMP-2
HDFPNoImmune BiologyDermal fibroblasts + Peripheral blood mononuclear cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, M-CSF, MMP-1, sIL-10, sIL-17A, sIL-17F, sIL-2, sIL-6, SRB, sTGF-β 1, sTNF-α, sVEGF
HDFSAgAutoimmune Disease, Chronic Inflammation, Rheumatoid ArthritisDermal fibroblasts + Peripheral blood mononuclear cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, M-CSF, MMP-1, sIL-10, sIL-17A, sIL-17F, sIL-2, sIL-6, SRB, sTGF-β 1, sTNF-α, sVEGF
HNoVascular BiologyVenular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, Proliferation, SRB
HPNoImmune Biology, Vascular BiologyPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, M-CSF, sPGE2, SRB, sTNF-α
HSM3CCardiovascular Inflammation, RestenosisVascular smooth muscle cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD40, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, Collagen I, Collagen IV, CXCL8/IL-8, CXCL9/MIG, Endothelin-1, HLA-DR, LDLR, M-CSF, PAI-I, Serum Amyloid A, SRB
K3CTDermatitis, Psoriasis, Skin BiologyKeratinocytesCCL2/MCP-1, CD54/ICAM-1, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, IL-1 α, MMP-9, PAI-I, SRB, TIMP-2, uPA
KF3CTDermatitis, PsoriasisDermal fibroblasts + KeratinocytesCCL2/MCP-1, CD54/ICAM-1, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, IL-1 α, MMP-9, PAI-I, SRB, TIMP-2, uPA
KFNoSkin BiologyDermal fibroblasts + KeratinocytesCCL2/MCP-1, CD54/ICAM-1, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, IL-1 α, MMP-9, PAI-I, SRB, TIMP-2, uPA
LPSCardiovascular Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, sPGE2, SRB, sTNF-α
MyoFChronic Inflammation, Fibrosis, Matrix Remodeling, Wound HealingLung fibroblastsbFGF, CD106/VCAM-1, Collagen I, Collagen III, Collagen IV, CXCL8/IL-8, Decorin, MMP-1, PAI-I, SRB, TIMP-1, α-SM Actin
MyoFNoFibroblast BiologyLung fibroblastsbFGF, CD106/VCAM-1, Collagen I, Collagen III, Collagen IV, CXCL8/IL-8, Decorin, MMP-1, PAI-I, SRB, TIMP-1, α-SM Actin
REMyoFChronic Inflammation, Matrix Remodeling, Renal Fibrosis, Wound HealingLung fibroblasts + Renal proximal tubule epithelial cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, E-Cadherin, EGFR, Keratin 8/18, M-CSF, MMP-1, MMP-9, N-Cadherin, PAI-I, sIL-6, sIL-8, SRB, sVEGF, TIMP-1, tPA, uPA, α-SM Actin
REMyoFNoRenal BiologyLung fibroblasts + Renal proximal tubule epithelial cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, E-Cadherin, EGFR, Keratin 8/18, M-CSF, MMP-1, MMP-9, N-Cadherin, PAI-I, sIL-6, sIL-8, SRB, sVEGF, TIMP-1, tPA, uPA, α-SM Actin
SAEMyoFChronic Inflammation, Matrix Remodeling, Pulmonary Fibrosis, Wound HealingLung fibroblasts + Small airway epithelial cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, E-Cadherin, EGFR, M-CSF, MMP-1, MMP-9, N-Cadherin, PAI-I, sIL-6, sIL-8, SRB, sVEGF, TIMP-1, uPA, α-SM Actin
SAEMyoFNoPulmonary BiologyLung fibroblasts + Small airway epithelial cellsCCL2/MCP-1, CD106/VCAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, E-Cadherin, EGFR, M-CSF, MMP-1, MMP-9, N-Cadherin, PAI-I, sIL-6, sIL-8, SRB, sVEGF, TIMP-1, uPA, α-SM Actin
SAgAutoimmune Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, Proliferation, SRB
SkMCMuscle BiologySkeletal muscle cellsGlycogen, SRB
SM3CCardiovascular Inflammation, RestenosisVascular smooth muscle cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD87/uPAR, Collagen I, Collagen IV, CXCL8/IL-8, CXCL9/MIG, HLA-DR, IL-6, LDLR, M-CSF, PAI-I, Proliferation, Serum Amyloid A, SRB
StroCHost Stromal Biology, Host Stromal-Tumor Microenvironment, Oncology, Oncology - CRC, Wound HealingPeripheral blood mononuclear cells + Primary human fibroblastsCD106/VCAM-1, CD87/uPAR, CEACAM5/CD66e, Collagen I, Collagen III, CXCL10/IP-10, Keratin 20, MMP-9, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-17A, sIL-2, sIL-6, SRB, sTNF-α, sVEGF, TIMP-2, tPA, uPA
StroHT29Host Stromal-Tumor Microenvironment, Oncology, Oncology - CRCHT-29 colon adenocarcinoma cell line + Peripheral blood mononuclear cells + Primary human fibroblastsCD106/VCAM-1, CD87/uPAR, CEACAM5/CD66e, Collagen I, Collagen III, CXCL10/IP-10, Keratin 20, MMP-9, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-17A, sIL-2, sIL-6, SRB, sTNF-α, sVEGF, TIMP-2, tPA, uPA
StroLHost Stromal-Tumor Microenvironment, Oncology, Oncology - NSCLCPeripheral blood mononuclear cells + Primary human fibroblastsCD106/VCAM-1, CD87/uPAR, Collagen III, CXCL10/IP-10, EGFR, HGF, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-13, sIL-17A, sIL-2, sIL-4, sIL-6, sMDC, sPGE2, SRB, sTNF-α, sVEGF, tPA, uPA
StroNSCLCHost Stromal-Tumor Microenvironment, Oncology, Oncology - NSCLCH1299 NSCLC cell line + Peripheral blood mononuclear cells + Primary human fibroblastsCD106/VCAM-1, CD87/uPAR, Collagen III, CXCL10/IP-10, EGFR, HGF, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-13, sIL-17A, sIL-2, sIL-4, sIL-6, sMDC, sPGE2, SRB, sTNF-α, sVEGF, tPA, uPA
VascCHost Vascular Biology, Host Vascular-Tumor Microenvironment, Inflammation, Oncology, Oncology - CRCPeripheral blood mononuclear cells + Primary human endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD40, CD69, CD87/uPAR, CEACAM5/CD66e, Collagen IV, CXCL10/IP-10, CXCL9/MIG, Keratin 20, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-17A, sIL-2, sIL-6, SRB, sTNF-α
VascHT29Host Vascular-Tumor Microenvironment, Oncology, Oncology - CRCHT-29 colon adenocarcinoma cell line + Peripheral blood mononuclear cells + Primary human endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD40, CD69, CD87/uPAR, CEACAM5/CD66e, Collagen IV, CXCL10/IP-10, CXCL9/MIG, Keratin 20, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-17A, sIL-2, sIL-6, SRB, sTNF-α
VascLHost Vascular-Tumor Microenvironment, Oncology, Oncology - NSCLCPeripheral blood mononuclear cells + Primary human endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD40, CD69, CD87/uPAR, CXCL10/IP-10, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-13, sIL-17A, sIL-2, sIL-4, sIL-6, sMDC, SRB, sTNF-α
VascNSCLCHost Vascular-Tumor Microenvironment, Oncology, Oncology - NSCLCH1299 NSCLC cell line + Peripheral blood mononuclear cells + Primary human endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD40, CD69, CD87/uPAR, CXCL10/IP-10, PAI-I, PBMC Cytotoxicity, sGranzyme B, sIFN-γ, sIL-10, sIL-13, sIL-17A, sIL-2, sIL-4, sIL-6, sMDC, SRB, sTNF-α