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EPIscan - Cell-Based Bromodomain & Histone Methyltransferase Assays

New!  EPIscan screening and profiling services provides a rapidly growing menu of cell-based bromodomain and histone methyltransferase (HMT) assays. Based on the novel InCELL Hunter™ technology, these assays provide a direct measure of compound permeability and binding in a native, cellular environment. Optimize your compounds based on binding and intracellular potencies and make more informed decisions about the therapeutic potential your lead compounds.


Experience You Can Trust

With EPIscan screening and profiling services, you can avoid expensive and time consuming assay development.  Our highly skilled and experienced service team is able to provide you high quality, reproducible data in a fraction of the time to help you meet all your project timelines and requirements.

Highlights and Benefits

  • High quality intracellular binding data
  • Rank ordering of compounds based on cellular potency
  • Broad applications - primary screening, lead optimization, SAR
  • Binding mode available
  • Rapid data turnaround
How it Works

Overview of EPIscan Services

Services Assays Pre-configured Panel Customizable? Standard Turnaround
ICH ELECT 1-8 No Yes 4 weeks
ICH E/IC50 ELECT 1-8 No Yes 4 weeks

EPIscan Bromodomain & Histone Methyltransferase Assay List

Below is a complete list of available cell-based bromodomain and histone methyltransferase assays available in the EPIscan panel.  List may be sorted by “Assay Name", "Common Name", “or Entrez Gene Symbol”.

Bromodomain Assays

Assay Name ▲Common NameAccession Number
BAZ2A NM_013449.3
Brd2(1)BRD2NM_005104.3
BRD2(1,2)BRD2NM_005104.3
BRD3(1)BRD3NM_007371.3
BRD3(1,2)BRD3NM_007371.3
Brd4(1)BRD4NM_058243
BrdT(1)BRDTNM_001242806
BRDT(1,2)BRDTNM_001726
EP300 NM_001429.3
G9aEHMT2NM_006709
GLPEHMT1NM_024757
PRMT3PRMT3NM_005788.3
SMARCA4 NM_001128844
TAF1L(2) NM_153809.2

Histone Methyltransferase Assays

Assay Name ▲Common NameAccession Number
G9aEHMT2NM_006709
GLPEHMT1NM_024757
PRMT3PRMT3NM_005788.3

EPIscan Panels

Target ▲ICHELECTICH E/ICT50 ELECT
BAZ2AYESYES
Brd2(1)YESYES
BRD2(1,2)YESYES
BRD3(1)YESYES
BRD3(1,2)YESYES
Brd4(1)YESYES
BrdT(1)YESYES
BRDT(1,2)YESYES
EP300YESYES
G9aYESYES
GLPYESYES
PRMT3YESYES
SMARCA4YESYES
TAF1L(2)YESYES