The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressiv...
/target-data-sheets/kinase/mtor
2/12/2015 9:47:37 PM
/products/proteins/14-770
/products/proteins/14-770m
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as ...
/target-data-sheets/kinase/ulk1
2/12/2015 9:48:35 PM
Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2 lymphocyte (Th2) mediated responses, TSLP is believed to play a key role in allergic diseases including asthma. The ...
/tools-resources/publications-references/publications/phenotypic-strategy-inhibit-tslp-lung-epitheli-(1)
1/24/2020 10:29:02 AM
/products/proteins/14-772
/products/proteins/14-772m
/products/reagent/wortmannin-92-1095
Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell ...
/tools-resources/document-resource-library/documents/predictive-models-for-mechanism-of-action-clas-(1)
4/1/2014 10:14:48 PM
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol
3/4/2016 8:11:57 PM
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