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PrecisION® Recombinant hERG Potassium Ion Channel Membrane Preparation

/products/membrane-preps/cyl4039 5/2/2023 11:54:33 AM
PrecisION® hERG Recombinant Stable Cell Line

/products/cell-line/stable-cell-line/cyl3038
PrecisION® hERG Recombinant Stable Cell Line

/products/cell-line/stable-cell-line/cyl3039
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Introduction: hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantification of experimental variabi...
/tools-resources/publications-references/publications/herg-block-potency-cardiac-safety-paradigm 9/23/2020 10:21:46 PM
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability o...
/tools-resources/publications-references/publications/variability-automated-patch-clamp-cardiac-currents 9/23/2020 11:11:43 PM
Potassium voltage-gated channel, subfamily H (eag-related), member 2 (hERG)

/target-data-sheets/ion-channel/kcnh2(g601s) 8/1/2015 1:42:20 AM
Ion Channels
Characterization Data Access Cell Lines and Membrane Preparation and Assay Products and Validation Data by Ion Channel Target Families   Family Protein Family Protein Voltage-Gated Potassium Ion Channels View hERG Validation Data View Potassium Validati...
/targets/ion-channel-solutions 5/10/2019 4:41:29 PM
Applications & Products
Contact a Specialist Eurofins DiscoverX Applications and Products Eurofins DiscoverX ® is committed to enabling and accelerating your multi-modality drug discovery and development from discovery to QC lot release by providing you with one of the industry’s broadest and...
/products-applications 8/9/2012 6:13:20 PM
Targets
Contact a Specialist Eurofins DiscoverX Target Families Eurofins DiscoverX offers a comprehensive portfolio of product solutions against a broad range of target classes for basic research through drug discovery and development programs.   Browse by Target A-Z L...
/targets 8/9/2012 6:12:27 PM
Membrane Preps
Applications Assay Principle Product Highlights Advantages of Membrane Preps Robust Performance – Large signal-to-background ratios with specific and high ligand binding capacity Reproducible – Produced from stable clonal cell lines for superior protein expression and ...
/products-applications/membrane-preps 9/24/2019 1:08:52 PM
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