PrecisION® Recombinant hERG Potassium Ion Channel Membrane Preparation

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PrecisION® hERG Recombinant Stable Cell Line

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PrecisION® hERG Recombinant Stable Cell Line

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A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

Introduction: hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantification of experimental variabi...

/tools-resources/publications-references/publications/herg-block-potency-cardiac-safety-paradigm 9/23/2020 10:21:46 PM

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability o...

/tools-resources/publications-references/publications/variability-automated-patch-clamp-cardiac-currents 9/23/2020 11:11:43 PM

[SPS 2022] Integrated Cardiac Proarrhythmic Risk Assessment Using Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes

  The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is an effort to improve the accuracy of proarrhythmic risk assessment by reducing the focus on in vitro hERG channel assays and in vivo QT interval measurements.

/tools-resources/document-resource-library/documents/integrated-cardiac-proarrhythmic-risk-assessment-u 9/16/2022 11:04:33 PM

Potassium voltage-gated channel, subfamily H (eag-related), member 2 (hERG)

/target-data-sheets/ion-channel/kcnh2(g601s) 8/1/2015 1:42:20 AM

Ion Channels

Characterization Data Access Cell Lines and Membrane Preparation and Assay Products and Validation Data by Ion Channel Target Families   Family Protein Family Protein Voltage-Gated Potassium Ion Channels View hERG Validation Data View Potassium Validati...

/targets/ion-channel-solutions 5/10/2019 4:41:29 PM

[DOT 2021] Integrated Cardiac Proarrhythmic Risk Assessment Using Human-Induced Pluoripotent Stem Cell (hiPSC)-Derived Cardiomyocytes Assays for Proinflammatory Cytokines

The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative is an effort to improve the accuracy of proarrhythmic risk assessment by reducing the focus on in vitro hERG channel assays and in vivo QT measurements. This novel approach includes the use of adult human ind...

/tools-resources/document-resource-library/documents/integrated-cardiac-proarrhythmic-risk-assessment 10/13/2021 9:58:47 PM

Applications & Products

Contact a Specialist Eurofins DiscoverX Applications and Products Eurofins DiscoverX is committed to enabling and accelerating your multi-modality drug discovery and development from discovery to QC lot release by providing you the broadest and most comprehensive colle...

/products-applications 8/9/2012 6:13:20 PM