2/6/2013 3:18:51 AM
Contact a Specialist Monitor responses to pathway stimulation at the receptor level with PathHunter Degradation Assays. These assays allow for profiling of small molecules or biologics that induce degradation of key signaling nodes (e.g. NIK or IƙB) through chec...
8/15/2012 6:09:43 PM
Mebendazole (MBZ) was recently shown to induce a tumor suppressive M1 phenotype in THP-1 monocytes and macrophages. In the present study the immune effects of MBZ was further investigated using human peripheral blood mononuclear cells (PBMCs) co-cultured with tumour cells. Th...
4/9/2019 10:56:33 AM
THE CHALLENGE Our client, a global integrated pharmaceutical company, entered the lead optimization stage with three p38MAPK antagonists. All three compounds were competitive inhibitors for ATP binding and indicated to treat rheumatoid arthritis (RA). At the time the client a...
1/28/2013 5:25:03 PM
Applications Assay Principles Contact a Specialist Eurofins DiscoverX offers a variety of cell-based assays for COVID-19 drug discovery and development programs. Contact custom assay development for additional assays or visit Eurofins Discovery to learn more about cell...
9/30/2020 3:15:11 PM
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